PlaF dimerization, mediated solely through the intermolecular interactions of TM and juxtamembrane regions, inhibits its activity. We present a 2.0-Å-resolution crystal structure of PlaF, the first structure that reveals homodimerization of a single-pass transmembrane (TM) full-length protein. aeruginosa Δ plaF mutant showed strongly attenuated virulence in Galleria mellonella and macrophages. PlaF is an important virulence factor, as the P. Here, we identified the first cytoplasmic membrane-bound phospholipase A 1 (PlaF) from Pseudomonas aeruginosa, which might be involved in the Lands cycle. Thus far, the function of intracellular phospholipases A (PLAs) in GPL remodeling (Lands cycle) in bacteria is not clearly established. While the regulation of membrane homeostasis via GPL synthesis in bacteria has been studied in detail, the mechanisms underlying the controlled degradation of endogenous GPLs remain unknown. Institute of Bio- and Geosciences (IBG-1: Biotechnology), Forschungszentrum Jülich GmbH, Germany Ĭells steadily adapt their membrane glycerophospholipid (GPL) composition to changing environmental and developmental conditions.Department of Molecular Bacteriology, Helmholtz Centre for Infection Research, Germany.Department of Microbiology, and Immunobiology, Harvard Medical School, United States.Institute of Bio- and Geosciences, Plant Sciences (IBG-2), and Agrosphere (IBG-3), Forschungszentrum Jülich GmbH, Germany.Institute for Plant Genetics, Heinrich Heine University Düsseldorf, Germany.Institute of Molecular Physiology, and Biotechnology of Plants (IMBIO), University of Bonn, Germany.John von Neumann Institute for Computing (NIC), Jülich Supercomputing Centre (JSC), and Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülich GmbH, Germany.Centro de Bioinformática y Simulación Molecular (CBSM), Faculty of Engineering, University of Talca, Chile.Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Germany.Institute of Biological Information Processing - Structural Biochemistry (IBI-7: Structural Biochemistry), Forschungszentrum Jülich GmbH, Germany.Institute of Molecular Enzyme Technology, Heinrich Heine University Düsseldorf, Forschungszentrum Jülich GmbH, Germany.
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